in the room with their father, and frequently on the bed with
him. The mother consulted me on the propriety of inoculating
them, but objected to my taking the matter from their father, as
he was subject to erysipelas. I advised her by all means to have
them inoculated at that time, as I could not procure any
variolous matter elsewhere. However, they were inoculated with
vaccine matter, but I cannot say I flattered myself with its
proving successful, as they had previously been so long and still
continued to be exposed to the variolous infection.
Notwithstanding this I was agreeably surprised to find the
vaccine disease advance and go through its regular course; and,
if I may be allowed the expression, to the total extinction of
the smallpox."

Mr. Jenner's cases were not less satisfactory. He writes as
follows:

"A son of Thomas Stinchcomb, of Woodford, near Berkeley, was
infected with the natural smallpox at Bristol, and came home to
his father's cottage. Four days after the eruptions had appeared
upon the boy, the family (none of which had ever had the
smallpox), consisting of the father, mother, and five children,
was inoculated with vaccine virus. On the arm of the mother it
failed to produce the least effect, and she, of course, had the
smallpox, [Footnote: Under similar circumstances I think it would
be advisable to insert the matter into each arm, which would be
more likely to insure the success of the operation.--E. J.] but
the rest of the family had the cow-pox in the usual way, and were
not affected with the smallpox, although they were in the same
room, and the children slept in the same bed with their brother