who was confined to it with the natural smallpox; and
subsequently with their mother.

"I attended this family with my brother, Mr. H. Jenner."

The following cases are of too singular a nature to remain
unnoticed.

Miss R--, a young lady about five years old, was seized on the
evening of the eighth day after inoculation with vaccine virus,
with such symptoms as commonly denote the accession of violent
fever. Her throat was also a little sore, and there were some
uneasy sensations about the muscles of the neck. The day
following a rash was perceptible on her face and neck, so much
resembling the efflorescence of the scarlatina anginosa that I
was induced to ask whether Miss R--had been exposed to the
contagion of that disease. An answer in the affirmative, and the
rapid spreading of the redness over the skin, at once relieved me
from much anxiety respecting the nature of the malady, which went
through its course in the ordinary way, but not without symptoms
which were alarming both to myself and Mr. Lyford, who attended
with me. There was no apparent deviation in the ordinary progress
of the pustule to a state of maturity from what we see in
general; yet there was a total suspension of the areola or florid
discolouration around it, until the scarlatina had retired from
the constitution. As soon as the patient was freed from this
disease this appearance advanced in the usual way. [Footnote: I
witnessed a similar fact in a case of measles. The pustule from
the cow-pock virus advanced to maturity, while the measles
existed in the constitution, but no EFFLORESCENCE appeared around