loose texture, and subsequently the formation of limpid fluid at
its edges. As these people were all employed in laborious
exercises, it is possible that these anomalous appearances might
owe their origin to the friction of the clothes on the newly
inflamed part of the arm. I have not yet had an opportunity of
exposing them to the smallpox.

In the early part of this inquiry I felt far more anxious
respecting the inflammation of the inoculated arm than at
present; yet that this affection will go on to a greater extent
than could be wished is a circumstance sometimes to be expected.
As this can be checked, or even entirely subdued, by very simple
means, I see no reason why the patient should feel an uneasy hour
because an application may not be absolutely necessary. About the
tenth or eleventh day, if the pustule has proceeded regularly,
the appearance of the arm will almost to a certainty indicate
whether this is to be expected or not. Should it happen, nothing
more need be done than to apply a single drop of the aqua
lythargyri acetati [Footnote: Extract of Saturn.] upon the
pustule, and, having suffered it to remain two or three minutes,
to cover the efflorescence surrounding the pustule with a piece
of linen dipped in the aqua lythargyri compos. [Footnote: Goulard
water. For further information on this subject see the first
Treatise on the Var. Vac., Dr. Marshall's letters, etc.] The
former may be repeated twice or thrice during the day, the latter
as often as it may feel agreeable to the patient.

When the scab is prematurely rubbed off (a circumstance not
unfrequent among children and working people), the application of
a little aqua lythargyri acet. to the part immediately coagulates